PRC is pleased to offer Saturday appointments

Become an Egg Donor

Call 866.423.2645

PRC is pleased to offer Saturday appointments

Call 866.423.2645

Fertility Medications

How Fast Does Clomid Work in Severe Infertility Cases?

Clomid is a fertility drug used to stimulate eggs that form in and are released from the ovaries. The drug has been known to result in multiple pregnancies, but 90% of couples who use this have singletons (one baby). Clomid is truly a miracle medication for couples who have severe infertility issues.

Severe Infertility CasesGetting Pregnant with Clomid

Clomid (clomiphene citrate) is a well-known fertility drug. This medication is taken by mouth once a day for five days before ovulation. Clomid is only available by prescription, and fertility tests are first done to determine if a woman’s infertility is related to lack of ovulation. Clomid stimulates the ovaries to produce more egg follicles, which are located in the ovaries. This will increase her chances of getting pregnant. Due to an increase in numbers of eggs released, multiple pregnancies are likely.

Despite the popularity of Clomid, it has many side effects. These range from mild to serious. The doctor who prescribes Clomid is a fertility specialist, and he will give you details about the side effects. Mild side effects are treated at home. These include flushing, feeling warm, nausea, breast tenderness, headaches, and spotting.


How Fast Does Clomid Work

One cycle of Clomid can result in pregnancy. For women under age 35 with polycystic ovarian syndrome (PCOS), Clomid can increase pregnancy success rates. This drug also will improve ovulation and egg maturation when used appropriately. Be sure to take it as prescribed. If you do not become pregnant after the first cycle, the fertility specialist will have you continue taking the drug for several months.

While it is not common to get pregnant after the first cycle of Clomid, it does happen. However, it usually takes 2 or more cycles to achieve pregnancy. Clomid only is one component of a successful pregnancy. Live birth rates depend on other factors, such as the progesterone levels. Be sure you consult with a fertility specialist regarding your entire treatment and available options.


Success Rates of Clomid

So, what are your chances of getting pregnant on Clomid in the first month? Clomid has a high success rate, so it remains a very popular fertility medication. Clomid results in 92% single births, 7% twin births, and around 1% triplets or multiples. When using Clomid, multiple pregnancy rates are much higher than natural multiple conception rates. In normally-conceived pregnancies, the percentage of women who conceive twins is only 1%, so Clomid greatly increases these chances.

Clomid is often prescribed for other health and fertility problems. When given for male fertility, Clomid helps men with low sperm and/or poor sperm mobility. Clomid stimulates the glands to produce heartier sperm but does not increase chances of multiple births when the male uses it.


Severe Infertility and Clomid

Clomid is known to work within the first 3-6 cycles. However, some women must take it for a year or longer. Extended treatment with this drug is not recommended. For severe infertility, such as in women with PCOS, the fertility specialist may use metformin in combination with Clomid. Metformin facilitates normal ovulation by correcting insulin levels and lower male androgens.

Clomid works by facilitating ovulation, so it does not result in a high number of eggs. In fact, once ovulation occurs regularly, there is no need to increase the dosage. Follicle-stimulating hormone (FSH) stimulates the ovaries directly, so doses of this are monitored carefully when it is used in fertility treatment.

Scheduled for Hysterectomy? Study Shows You May Not Need It!

Hysterectomy is the second most prevalent type of surgery that women of reproductive age undergo in the USA because it can address a number of female medical conditions as the last resort; however, new research says that about a fifth of all hysterectomies performed in the US may no longer be necessary for the future.

Hysterectomy - Female Reproductive Organ SurgeryHold the Surgery!

In a study that was recently published in the American Journal of Obstetrics & Gynecology, data showed that 20% of hysterectomies done as treatment to non-cancerous medical conditions may have alternative treatments and are not necessary. The study also suggests that alternative therapies and treatments are underutilized.

A 20% reduction is significant because it is projected that 1 in every 3 American women will have a hysterectomy by the time they reach age 60. This figure remains true although figures have fallen from 680,000 in 2002 to just around 434,000 in 2010.

Melissa Goist, OB-GYN and assistant professor at The Ohio State University Wexner Medical Center in Columbus shared that a hysterectomy is a serious surgery that entails the surgical extraction of the uterus (sometimes including the cervix, ovaries, and fallopian tubes) that can pose a serious risk of injury because major organs and blood vessels are moved around during the procedure.

Because of the above, complications following a hysterectomy can include bleeding and blood clots in the deep veins of the body, damage to internal organs such as the bladder and bowels, complications with anesthesia use, and infections. More so, because the uterus is taken away, a woman who’ve had a hysterectomy will no longer be able to get pregnant and will no longer have menstrual periods.

Who Are Candidates for Hysterectomy?

The above is not to say that the risks of having a hysterectomy outweigh the benefits. In cancerous conditions and other life-threatening medical issues, taking out the diseased organ is an absolute necessity to save the woman’s life.

Hysterectomies are used as a surgical intervention for cancers affecting the uterus, fallopian tubes, cervix, and ovaries. It is also used to treat uterine prolapse, chronic pelvic pain, severe endometriosis, and uterine fibroids. It should be noted that the majority of hysterectomies are performed to those diagnosed with benign conditions.

Women’s health specialist and OB-GYN Sheryl Ross says that she isn’t surprised by the findings but thinks that women should be given alternatives therapies prior to being told to undergo a hysterectomy. She further added that alternative treatments such as the use of hormones can treat benign gynecological medical conditions and that doctors are underutilizing them.

Alternatives to Look Into

Ross shared that women diagnosed with fibroids can ask their doctors about uterine artery embolization that may help shrink the uterine masses. Myectomy can also be an option instead of taking out the entire uterus, thus preserving fertility. For those with severe and chronic bleeding, endometrial ablation might be the answer and that the use of a pessary and Kegel exercises may help support the uterus of women with uterine prolapse.

Ross further added that those who are truly in need of a hysterectomy are women who’ve already tried and failed non-surgical options. Goist agreed to this and recommended that women should be pro-active in asking their doctors regarding alternative treatments. After all, a gynecological surgeon’s primary responsibility is to give the patient the best possible treatment.

Oral Contraceptives Pose a Threat to Healthy Women?

A recently published study shared that the most common combined oral contraceptive pill pose a negative impact on the quality of life of women who use the said pills; although it does not cause an increase in depressive symptoms.

The above findings were published in the scientific journal Fertility and Sterility earlier this year. The data was collected from a major randomized placebo-controlled study conducted by the collaborative efforts of Sweden’s Karolinska Institutet researchers and the Stockholm School of Economics.

Oral ContraceptivesNew OCP Study Sheds Light on Important Issue

Karolinska Institutet Department of Women’s and Children’s Health professor Angelica Lindén Hirschberg stated that we know very little as to how oral contraceptive pills truly affect women’s health, despite the fact that women users of contraceptive pills around the world number at around 100 million (some males on hormone therapy also use them). She also shared that the current scientific base regarding the effect of contraceptive pills on depression and quality of life is very limited. Due to this, the professor thinks that there is a great need for studies wherein the use of oral contraceptives is compared to placebos to ascertain what other effects it may have on women’s health and fertility.

In light of the above, professor Lindén Hirschberg led a study together with the Department of Learning, Informatics, Management and Ethics associate professor Niklas Zethraeus, Stockholm School of Economics’ Anna Dreber Almenberg, and the University of Zürich Eva Ranehill to gather necessary data. The research team gathered their study’s data from a group of 340 healthy women belonging to the 18 to 35 years old age group. The women were treated randomly for over 3 months with placebos (pills that have no effect) or contraceptive pills that contain a combination of levonorgestrel and ethinylestradiol, the most common form of combined OCP in the world and in Sweden. The lead researchers and the women were kept unaware as to which treatment was given to each woman.

Findings Could Mean More

Women who were given OCPs estimated that their quality of life is lower than women who were treated with placebos. It appears that the contraceptives negatively affected both the general quality of life and aspects of it such as the women’s well-being and mood. It is to be noted that no marked increase in depressive symptoms was seen.

The researchers emphasize that caution must be applied to the interpretation of the study’s results since changes observed were relatively small. Despite this, they also stated that the negative effect of the use of OCPs in individual women may be of clinical importance.

Clinical Application

Niklas Zethraeus stated that the negative effect shared by some women may be a contributing factor to the irregular use or low compliance of use of OCPs in some women. Zethraeus further added that these findings should be taken into consideration when prescribing various forms of contraceptives and specific OCPs.

It is to be noted that the findings of the study are only applicable to the specific OCP combination of ethinylestradiol and levonorgestrel – the most common OCP combination prescribed in most countries due to a relatively lower risk of physiological combinations among other OCPs. Other OCP combinations have a different risk profile and possible side effects.

What are the Chances of getting Pregnant with Twins on Clomid?

In the United States and Europe, Clomid (clomiphene citrate) is a commonly prescribed fertility drug. This medication is often ordered as to help stimulate the ovaries and to assess for ovulation. Clomid forces the body to produce more hormones and egg follicles than usual, so the woman will develop more than one mature egg. Because of extra eggs, the chances of getting pregnant with twins is increased.clomid1

Clomid Success Rates

Clomiphene citrate has been used for fertility treatment for over 50 years. The goal of treatment is to induce ovulation and normalize menstrual cycles. Of women prescribed Clomid, 80% successfully ovulate, but only 50% of these women will go on to get pregnant.

One thing that limits the success of Clomid is side effects, such as cervical mucus changes and endometrial effects. In addition, another factor that affects success rates of Clomid is that many women have secondary infertility factors. In a recent study, researchers found that 87% of women who ovulate on Clomid have an additional cause of infertility, such as tubal disease, pelvic lesions, and endometriosis.

The Numbers

For women who get pregnant naturally, the chance of having twins is around 2%. However, taking Clomid increases a woman’s chances of delivering twins, but not drastically. According to statistics, Clomid causes twin pregnancies around 10% of the time, and less than 1% of women taking Clomid have triplets or quadruplets.

According to one clinical trial, 0.5% of women on Clomid had triplets, and 0.3% had quadruplets. Of women who conceive twins, most children are not identical. According to clinical studies, only 1 of 5 twin pregnancies resulting from Clomid therapy are identical twins. This means 80% of twin pregnancies result in fraternal twins.

Factors that Increases Twin Rates on Clomid

Certain factors increase the likelihood of a woman delivering twins while taking Clomid. These include:

  • Age – Women younger than 25 years of age are more likely to have twins while on tubal-reversalClomid.
  • Ovulation – Only women who have trouble ovulating should take Clomid. Anyone who ovulates regular, and takes this drug, has an increased chance of having twins.
  • Dose – Taking more than the recommended dose of Clomid increases chances of delivering twins.

How Clomid Works

Clomiphene citrate works by blocking the effects of estrogen in your body. By blocking estrogen action, this effect tricks your body to produce FSH and LH, which are hormones necessary for ovulation. FSH causes the eggs to mature in the ovaries, and LH triggers the eggs release from the follicles. You take Clomid in pill form for five days of your menstrual cycle, and as long as six months.

Most women are advised to start Clomid within five days of the period. Progesterone is also given to keep your reproductive cycle regular and to re-establish periods if you have irregular menses. Ovulation is expected between 5-9 days after you have taken the last Clomid pill. It is possible that you ovulate and conceive in the first month, or it may take several months before you ovulate regularly. For some women, treatment is continued for a full year. Unfortunately, not all women respond to Clomid.

Side Effects

Clomiphene citrate, like all medications, has some side effects. Make sure to talk to your local Los Angeles fertility doctors if you have any concerns. These include:

  • Mood swingsxpreimplantation-genetic-testing
  • Hot flashes
  • Blurred vision
  • Dizziness
  • Weight gain
  • Heavy periods
  • Breast tenderness

With clinics throughout Southern California, call Pacific Reproductive Center today!