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PRC is pleased to offer Saturday appointments

Call 866.423.2645


What is Femara Infertility?

Femara (letrozole) is an effective drug that is thought to be better for helping women become pregnant who have polycystic ovary syndrome (PCOS). A study by the National Institutes of Health found that PCOS affects around 7% of reproductive age women, and is one of the most common causes of female infertility.

Femara infertility drug is utilized to increase the probability of pregnancy in women with fertility issues. While Clomid is known to last longer, letrozole is helpful in inducing an egg to develop and be released. Fertility rates with letrozole are similar to those seen with Clomid, but older patients have a reduced chance of success when compared ot younger persons.


Femara InfertilityWhat is PCOS?

Women with PCOS produce an excess of male hormones (androgens), which affect and interfere with ovulation. With PCOS, the ovaries become enlarged and contain multiple cyst-like structures. These cysts are immature ovarian follicles that produce androgens. Women with PCOS often have insulin resistance, and researchers have found that treatment with letrozole assists these women with ovulation.

For women with PCOS, lifestyle changes can facilitate conception. Losing weight is one of the best things a person can do to improve fertility. Your fertility specialist may recommend that you attempt to lose weight, and this will restore ovulation and improve pregnancy rates. In a recent clinical study involved 11 women with PCOS, who lost more than 5% of their initial weight. Out of 11, nine of these women became pregnant or had a regular menstrual cycle.


What are the Side Effects of Letrozole?

Letrozole is an aromatase inhibitor, which means it increases intraovarian hormones. This will increase follicular sensitivity to follicle-stimulating hormone (FSH). By augmenting FSH receptors and stimulating insulin-like growth factor, FSH promotes follicular growth. This may result in pelvic discomfort, breast tenderness, and bloating. Letrozole has some benefits over Clomid. It keeps the feedback mechanism intact and is short-acting.

Letrozole is currently used as a breast cancer treatment for women who have gone through menopause. It inhibits the production of estrogen, which in turn, influences the brain’s hypothalamus and pituitary glands. This results in ovarian function. The side effects of letrozole include:

  • Nausea
  • Headaches
  • Increased risk of birth defects


Letrozole Fertility Success Rates

In an NIH study, the chief of Fertility and Infertility, Dr. Legro, found that letrozole given on day 3 of the menstrual cycle, and taken for five days, would improve chances of successful ovulation. Of the women who received letrozole in the study, 28% had a live birth, which was compared to 19% of those taking clomiphene. The letrozole group ovulated 688 times out of 1,425 cycles (a 49% success rate).

According to a recent review of studies, letrozole is being used for adenomyosis and endometriosis as “off-label” treatment. In addition, letrozole has been studied for anovulatory conditions. In controlled trials, the ovulation rate was higher in the letrozole group and was found to be better than anastrozole in ovulation and pregnancy rates. For ovarian stimulation for intrauterine insemination (IUI), women who took the drug had higher pregnancy rates.


Kar S (2013). Current evidence supporting “letrozole” for ovulation induction. J Hum Reprod Sci, 6(2), 93-98.
National Institutes of Health (2014). New treatment increases pregnancy rate for women with infertility disorder. Retrieved from:

How Fast Does Clomid Work in Severe Infertility Cases?

Clomid is a fertility drug used to stimulate eggs that form in and are released from the ovaries. The drug has been known to result in multiple pregnancies, but 90% of couples who use this have singletons (one baby). Clomid is truly a miracle medication for couples who have severe infertility issues.

Severe Infertility CasesGetting Pregnant with Clomid

Clomid (clomiphene citrate) is a well-known fertility drug. This medication is taken by mouth once a day for five days before ovulation. Clomid is only available by prescription, and fertility tests are first done to determine if a woman’s infertility is related to lack of ovulation. Clomid stimulates the ovaries to produce more egg follicles, which are located in the ovaries. This will increase her chances of getting pregnant. Due to an increase in numbers of eggs released, multiple pregnancies are likely.

Despite the popularity of Clomid, it has many side effects. These range from mild to serious. The doctor who prescribes Clomid is a fertility specialist, and he will give you details about the side effects. Mild side effects are treated at home. These include flushing, feeling warm, nausea, breast tenderness, headaches, and spotting.


How Fast Does Clomid Work

One cycle of Clomid can result in pregnancy. For women under age 35 with polycystic ovarian syndrome (PCOS), Clomid can increase pregnancy success rates. This drug also will improve ovulation and egg maturation when used appropriately. Be sure to take it as prescribed. If you do not become pregnant after the first cycle, the fertility specialist will have you continue taking the drug for several months.

While it is not common to get pregnant after the first cycle of Clomid, it does happen. However, it usually takes 2 or more cycles to achieve pregnancy. Clomid only is one component of a successful pregnancy. Live birth rates depend on other factors, such as the progesterone levels. Be sure you consult with a fertility specialist regarding your entire treatment and available options.


Success Rates of Clomid

So, what are your chances of getting pregnant on Clomid in the first month? Clomid has a high success rate, so it remains a very popular fertility medication. Clomid results in 92% single births, 7% twin births, and around 1% triplets or multiples. When using Clomid, multiple pregnancy rates are much higher than natural multiple conception rates. In normally-conceived pregnancies, the percentage of women who conceive twins is only 1%, so Clomid greatly increases these chances.

Clomid is often prescribed for other health and fertility problems. When given for male fertility, Clomid helps men with low sperm and/or poor sperm mobility. Clomid stimulates the glands to produce heartier sperm but does not increase chances of multiple births when the male uses it.


Severe Infertility and Clomid

Clomid is known to work within the first 3-6 cycles. However, some women must take it for a year or longer. Extended treatment with this drug is not recommended. For severe infertility, such as in women with PCOS, the fertility specialist may use metformin in combination with Clomid. Metformin facilitates normal ovulation by correcting insulin levels and lower male androgens.

Clomid works by facilitating ovulation, so it does not result in a high number of eggs. In fact, once ovulation occurs regularly, there is no need to increase the dosage. Follicle-stimulating hormone (FSH) stimulates the ovaries directly, so doses of this are monitored carefully when it is used in fertility treatment.

Egg Donation – Should You Donate Your Eggs Or Not?

A few years ago, egg donation was often viewed as a cringe-worthy topic that few would dare speak out about in public. The stigma is not because it is a taboo topic but more of a by-product of inadequate information regarding it. Things are changing nowadays.

Human Egg Donation for infertilityWhat is Human Egg Donation?

Human egg donation is a medical process that usually begins by stimulating a young, healthy woman’s ovaries to produce extra eggs. The eggs are then retrieved and then made available to women who are struggling with infertility.

A huge percentage of egg donors are women who donate their eggs to close friend and family, however, some women are recruited by egg donation agencies or fertility clinics to join a registry for anonymous egg donors. Couples who are seeking healthy eggs are able to select from the registry whose eggs they will be used to produce a healthy child.

Who Will Benefit From an Egg Donation

It is not just women who have primary infertility that will benefit from a donor’s gracious egg donation. Many women these days are delaying childbearing and may become ready to be mothers when the quality of their eggs no longer match the ability of their uterus to bring a child to term. This further increases the demand for egg donors, a fact supported by a statement from Michelle Purcell, a nurse at Shady Grove Fertility who shared that about 15,000 women apply to be egg donors in their facility every year.

Are You Ready to be An Egg Donor?

If you are thinking of being an egg donor, you need to understand that there is the possibility of rejection and that your future child may not even know who you are. Below are some things to check to determine if you are indeed ready to donate your eggs.

Research on Your Eligibility

Most fertility clinics in the US have an egg donor approval rate of about 3%. This is because egg donors have a rigid screening method wherein the women’s age, physical location, health status, smoking history, sexual history, and familial history of diseases and disorders are taken into consideration.

Find Out What to Expect

Becoming an egg donor is not easy. There are lengthy applications to fill up, detailed physical and psychological exams to undergo, genetic testing to be done, and other tests to be completed.

Know that the entire process will take months because once you are selected as a donor, your menstrual cycle will have to be adjusted to match your egg’s recipient and that you will be given medications that will spur your egg production (this is partly why donors have to undergo psychological evaluation).

Understand the Risks

Because the process of egg donations means that the donor will be given fertility drugs and will have to undergo an invasive procedure to extract the eggs, it comes with certain health risks (this is why the first step was to screen for health issues, to begin with) that the doctor will talk to you about. It is just easier to know them beforehand.

Are You Doing It with the Right People for the Right Reasons

The right facility to donate eggs to won’t jump at any donor available. They will be careful with regards to every aspect of the egg donation process. They will make sure that you have a full understanding of what the process entails and will have specialists to support you medically, legally, and psychologically. They know that being selected as an egg donor is worth a lot more than the compensation of several thousand dollars. They want you to appreciate that egg donation is about choosing to share the gift of life.

Frozen vs. Fresh Embryos for IVF

In vitro fertilization (IVF) is a treatment where eggs are fertilized with sperm in the laboratory setting. The fertilized eggs grow in heated incubators to become embryos, which are then transferred to the mother’s uterus (fresh), or they are frozen (cryopreserved) for later use in future cycles.

In previous years, the prevailing thought in assisted reproductive technology (ART) was that fresh embryo transfer yielded higher success rates of pregnancy than frozen embryo transfers. However, according to the Society of Assisted Reproductive IVF Los AngelesTechnology (SART), for women age 35 years and older, the percentage of transfers that result in live births is higher with frozen embryo transfers. One factor contributing to success rates for pregnancy is the mother’s age at the time these eggs are frozen.

The Embryo Transfer Procedure

For the woman, the embryo transfer is much like a Pap smear. There is no pain, so drugs are not required. After drinking to obtain a full bladder, the doctor inserts a small catheter with the embryos through the end opening of the uterus (cervix) and up to the middle of the uterine cavity.

Using ultrasound guidance, the doctor watches on a monitor so the tip is advanced to the proper position. The embryos are then placed into the lining of the uterine cavity, which is called the endometrial lining. The catheter is the slowly retracted from the uterus.

Pros of Fresh and Frozen Embryo Cycles

  • With a fresh IVF cycle, the woman must take hormone treatment to regulate her menstrual period, stimulate ovulation, and assist with egg maturation. Once the eggs are mature, they are fertilized in the laboratory setting with the male partner’s sperm. A few days later, the embryos are transferred to the female partner’s uterus.
  • When a frozen embryo is used for an IVF cycle, the woman doesn’t have to take medicines for ovarian stimulation or egg retrieval, because it has been done previously. However, she does have to take estrogen and progesterone to prepare the uterus’ lining to receive the embryo.
  • Many women report that using frozen embryos for future IVF cycles is less stressful, because you do not have to go through the egg retrieval process.
  • There is a shorter timeframe from choosing a donor if frozen eggs are used for transfer.

Cons of Fresh and Frozen Embryo Cycles

  • With a fresh cycle, you have to take medications for ovarian stimulation, which costs may range from $4,000 to $9,500.
  • If you fail on the first IVF cycle, you will have to go through the entire process again if you wish to use a fresh embryo the second time.
  • A large clinical study found that the pregnancy success rate is 30% higher when using frozen embryos than fresh transfers.
  • The cost per cycle is more when fresh eggs are used for subsequent IVF cycles.

Success Rates using Frozen Donor Eggs

The success rate using frozen donor eggs depends on several factors, such as:

  • The ability of the clinic to perform effective freezing of the eggs, as well as thawing.
  • The quality of the donor eggs.
  • The number of embryos to be transferred.prc_logo
  • The number of eggs thawed.
  • The expertise of the IVF specialists.
  • The quality of the IVF program.

Variables that affect Success Rates

Several factors affect the success rates of both fresh and frozen embryos. These variables include:

  • Embryo survival after the freezing and thawing processes is related to the quality of the embryo.
  • During fresh cycles, subtle rises in progesterone levels before administration of hCG (pregnancy hormone) can affect implantation rates.

3 Urgent Signs You Need To Seek Infertility Treatment


Coming to terms with the realization that you need help getting pregnant may be complicated. Many couples keep waiting month after month to conceive even though it is clear that they may need medical help. The experts at leading infertility treatment center in Irvine, Pacific Reproductive Center, share top signs that indicate you should seek infertility treatment.


Fertility experts say that generally women over 35 should not wait for longer than 6 months and younger ones no longer than a year to get pregnant. If you have been trying without success for a long time, it is a clear sign that you need to see a fertility specialist at a reputed infertility treatment center such as Pacific Reproductive Center at Irvine.


Repeated pregnancy loss or miscarriages indicate that something is wrong. This can mean hormonal issues, chromosomal abnormalities, or structural issues in the reproductive system. If you are in Los Angeles or Irvine, you should immediately see a fertility medicine expert at the top great fertility treatment center, Pacific Reproductive Center.


Have you been having irregular or missed periods? This could be due to several reasons. A good fertility expert will be able to find out what is wrong and suggest the best treatment possible. When you seek help at the best fertility center in Los Angeles, the doctors and the staff ensures that you get the best treatment, attention and care throughout the process.

4 Leading Causes of Male Infertility Now Treatable

Male infertility

According to clinical studies, around 35% of all infertility cases are related to male fertility issues. Male infertility can be caused due to several factors. Fortunately, male infertility treatment is now available at the top Fertility Treatment Clinic, Pacific Reproductive Center in Los Angeles. Male infertility can be divided into four main categories.

Pre-testicular causes

These are problems that occur due to some form of hormone deficiency, such as a problem with the pituitary gland or hypothalamus. Men who have this type of infertility often have underdeveloped male characteristics. As part of male infertility treatment at leading fertility treatment clinic, Pacific Reproductive Center Los Angeles, hormone imbalance correction can be treated using hormone replacement therapy or medications to restore body hormones.

Testicular causes

These problems can be genetic, based on birth defects, or testicular compromised from physical damage or toxins.

Sperm disorders

This includes problems with sperm transport, function, or motility. Male fertility treatment for sperm quality at Pacific Reproductive Center Los Angeles includes treatments such as IUI or Intrauterine Insemination where the sperms is washed and concentrated for insemination. This ensures that only the healthiest sperm is used.

Sexual dysfunction

This includes erectile dysfunction problems, premature ejaculation, and a decreased libido. Male fertility treatment at Pacific Reproductive Center Los Angeles for sexual dysfunction is done using medication.

Pacific Reproductive Center Los Angeles, top male fertility treatment clinic offers the latest treatments with Board Certified and highly experienced fertility specialists and compassionate staff.

Top 6 Reasons To Choose Pacific Reproductive Center

infertility center

There is no dearth of fertility clinics these days. But only the best offer the most modern treatment options with the care and compassion required on the path to conception. PRC doctors, give your concerns and fertility goals the utmost importance. Here are the six reason why you should choose PRC!


Pacific Reproductive Center fertility doctors have been consistently delivering results in the Southern California area for more than 25 years. Their services are available to couples in a state of the art facility at Pacific Reproductive Center Los Angeles and Glendale.

The Team

PRC is proud to have a team of the best fertility doctors, embryologists and staff. Specially trained and highly qualified doctors are dedicated to help you achieve your fertility goals. Board certified in reproductive endocrinology, physicians at PRC are certified in reproductive endocrinology and infertility.

Personalized attention

A dedicated team serving you ensures personalized care and attention at all times and a higher probability of success.

Latest Technology

PRC has been a pioneer in in-vitro fertilization and preimplantation genetic testing. Only the most modern treatments and latest technology is employed to deliver successful results.

Multiple Options

Our team of doctors will provide a variety of fertility treatment options, depending upon your condition and concerns.


One of the best fertility clinics in Los Angeles, CA, Pacific Reproductive Center is conveniently located in Glendale, Torrance, Irvine and Corona.

Overview of Infertility Causes and Treatments in Women

Infertility in Women

Approximately 10% of all women of reproductive age have trouble getting pregnant or maintaining a pregnancy. Female fertility doctorinfertility contributes to around 33% of all cases. Thanks to modern technology and advances in medical diagnostics, couples now have options for conception.

What are the risk factors for female infertility?

The risks factors for infertility in women include:

  • Age – After a woman reaches age 35, fertility begins to decline.
  • Weight – Extreme weight gain or loss contributes to infertility.
  • Smoking – Cigarette smoking is known to impair fertility in women.

What are the known causes of infertility in women?

Infertility can be the result of an underlying health condition that interferes with ovulation, damages the fallopian tubes, or causes hormone imbalances. Common causes of female infertility include:

  • Ovulation problems – The two main problems with ovulation include polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF). With PCOS, a woman does not ovulate regularly and produces excessive male hormones (androgens). This alters the hormone levels that are involved with egg production. With premature ovarian failure (early menopause), there is a depletion of follicles before age 40 years. Certain conditions contribute to this problem, particularly diseases that affect the thyroid, adrenal, and/or pituitary glands.


  • Blocked fallopian tubes – The tubes become scarred and blocked due to endometriosis or pelvic inflammatory disease (PID). With PID, chronic reproductive tract infection leads to inflammation of the tubes and scarring. Endometriosis involves growth of uterine cells outside the uterus, causing the tissue to become inflamed from hormonal changes. With blocked fallopian tubes, the egg cannot progress to become fertilized or to implant if fertilization does occur.


  • Uterine abnormalities – Adhesions can form following pelvic surgery, restricting the movement of the fallopian tubes and ovaries. In addition, uterine fibroids often block the fallopian tubes or distort the shape of the uterine cavity.


  • Elevated prolactin levels – Prolactin is produced by the pituitary gland, and this hormone stimulates milk production after pregnancy. With high levels, gonadotropin hormones are suppressed, which inhibits ovulation.


  • Egg quality – The quality and number of eggs decrease as a woman ages. Certain medical conditions can impair the ovaries. In addition, radiation/chemotherapy treatments often damage the ovaries, which affects egg development and quality.

How is female infertility diagnosed?

When a couple cannot conceive after one year of unprotected sex, infertility can be diagnosed. Testing involves finding the underlying cause of infertility. Before the woman undergoes invasive testing, the male partner should have a semen analysis.

  • Medical history/physical examination – The first step in a workup for female infertility is the medical history and physical examination. The doctor will ask questions about lifestyle issues, menstrual history, and current medications, as well as conduct a thorough examination.
  • Laboratory tests – this involves evaluation of hormone levels and ovarian reserve. With the Clomid challenge test, the fertility doctordoctor measures FSH, has the woman take Clomid, and then measures FSH again, assessing for sufficient levels. Tissues samples often are taken to assess for premature ovarian failure.
  • Diagnostic testing – Extensive diagnostic tests help reveal abnormal uterine or tube findings. These include ultrasound, hysteroscopy, hysterosalpingography, and laparoscopy.

How is female infertility treated?

Treatment for infertility in women should address the actual medical condition or cause of the fertility problem. Approaches for treatment are:

  • Lifestyle measures – This includes quitting smoking, maintaining a healthy weight, and avoiding alcohol.
  • Rhythm method – To increase chances of conception, the couple can time sexual activity according to ovulation.
  • Assisted reproductive technologies (ART) – These include in vitro fertilization, use of egg and/or sperm donors, and intracytoplasmic sperm injection.
  • Medications – Drugs can induce ovulation, such as gonadotrophins.

The top fertility specialists in Los Angeles metro are with Pacific Reproductive Center. With four locations, the California fertility clinics provide comprehensive treatments in the most minimally invasive fashion. Call us today for top fertility treatment, financing available!

4 Signs That You Should Seek Infertility Treatment


As you struggle to conceive, it’s easy to get stuck in the cycle of anxiety and disappointment, pushing you further and further away from your dream of being a parent. Seeking an infertility treatment consultation can easily become one of those things that you keep putting off, especially if you know you’re at crossroads and need to make a decision about to seek infertility treatment at Los Angeles and Irvine. Since fertility is largely affected by a woman’s age, it is important to do a reality check and evaluate your situation before it is too late.


On an average, it takes a couple 5 to 7 months to conceive. Younger women have a high chance of getting pregnantnaturally. The following women are recommended to see an infertility treatment specialist at Irvine and Los Angeles:

  • Women who are under 35 and have been trying to conceive for a year
  • Women who are 35 to 39 but no pregnancy even after 6 months of trying to conceive
  • Women who are 40 and want to conceive
  • Women who have trouble conceiving and also –
    • History of irregular menstrual periods or absent periods
    • Previous abdominal or gynecological surgery, pelvic inflammatory disease (PID), or other sexually transmitted infections (STIs)
    • Known structural abnormalities of the uterus or other reproductive organs
    • Endocrine (hormonal) disorders such as thyroid disease

Your infertility treatment specialist would begin with a full work-up to determine a customized treatment plan for you at Pacific Reproductive Fertility Center, Los Angeles and Irvine.

3 Most Important Things to Ensure A Successful Embryo Transfer During IVF

fertility clinics los angeles 

ivf Embryo Transfer day is the most important day of the IVF cycle. The day is the culmination of all your hopes and at the same time, your anxieties. So what do you do? Pacific Reproductive Center explain the truth about what needs to be done and what doesn’t on the embryo transfer day.

Request for the most experienced doctor

As a patient, it is your privilege to ask for the best doctor in the team. PRC doctors are extensively trained and experienced in infertility treatment and IVF. They have been instrumental in advancing the understanding and treatment of fertility and In Vitro Fertilization (IVF).

Discuss in advance about the number of embryos being transferred

Till very recently, doctors would transfer more than embryo to ensure that at least one would implant. But with modern technology, this may no longer be necessary. Preimplantation genetic diagnosis during your IVF fertility treatment procedure at Pacific Reproductive Center, LA ensures that the embryo being transferred is healthy and free from most inherited disorders. A healthy embryo has a greater chance of implanting, reaching full term and being born as a healthy baby.

Relax and trust the process

Do not give in to hearsay. Understand the process from your doctor well in advance. S/he is the one who knows what is best for you. PRC staff completely equipped and experienced enough to care for you throughout the IVF process. Bring your partner along for support. Although it is natural to be a little anxious, do not let stress take a toll. PRC has acupuncturists to help you reduce any stress and anxiety on your important IVF day and throughout the treatment.