PRC is pleased to offer Saturday appointments

Become an Egg Donor

Call 866.423.2645

PRC is pleased to offer Saturday appointments

Call 866.423.2645


PCOS

How to take Clomid for Twins and when to take it Properly?

take clomid for twinsClomiphene citrate (Clomid or Serophene) is a type of medication commonly used for infertility treatment. This drug is used to induce ovulation in women that do not develop and release an egg through ovulation on their own. Women who are anovulatory (do not ovulate without medications) often have medical conditions that alter hormone production, such as polycystic ovarian syndrome.

In certain cases, the use of Clomid increases the number of eggs released. Clomid works through an anti-estrogen” mechanisms that trick the brain into believing estrogen levels in the body are low. The drug does this by binding to estrogen receptors in the brain, blocking the ability of estrogen to bind and work. The brain, believing the body has low estrogen, releases GnRH hormone, which goes to the pituitary gland, stimulating the release of follicle stimulating hormone (FSH). This hormone stimulates the development of a mature follicle (egg structure) in the ovary.

 

How to take Clomid for Twins

If you are considering Clomid twins, the average ovulation occurs on days 10 through 14. This occurs after completing a course of Clomid pills. This varies a bit, depending on whether the woman ovulates regularly or not. Some women will ovulate before 10 days and some after 14 days. The protocol for taking Clomid is different for women who do not ovulate and those who have regular menstrual cycles.

After taking Clomid for twins, you should consider the best time for intercourse. Ovulatory kids are available at supermarkets and drugstores, and they are urine tests that women do at home. These ovulation predictor kits (OPKs) are designed to detect the presence of a woman’s LH surge. This surge begins around 36 hours before ovulation. The prediction kits are done once a day, and when positive, then sex should be that day or the following morning.

 

Best Days to take Clomid for Twins

The best days to take Clomid are 7-14 days after the medications begin. The ovulation prediction kit test is done each day. The egg lifespan is around 12-24 hours, and the woman has a 32-day cycle on Clomid, then she will ovulate around day 18. Ovulation occurs 14 days before the onset of the next menstrual cycle. The sperm can live in the female reproductive tract for 3-5 days, but the egg’s lifespan is only 12-24 hours. Therefore, intercourse a day or two before ovulation is fine, but sex 24 hours after ovulation will not help.

A typical Clomid cycle is day 10-14 of the cycle (five days before anticipated ovulation). However, when the woman has a 32- to 36-day cycle, this could be extended to days 10-18. Clomid cycles are usually monitored using follicle ultrasound scans and blood hormone levels. The blood hormone levels are done to determine the timing of intrauterine insemination (IUI) or sexual intercourse.

 

Clomid Twins

What is the percentage of conceiving multiples or twins on Clomid? In a large clinical study involving women taking Clomid, researchers found that 92% of pregnancies resulted in singletons (one baby), but 7% resulted in twins. The chances of having triplets was less than 1%, and quadruplets or more were very rare.

Clomid has an 80% success rate for ovulation, but only half of these women become pregnant. The limits of Clomid success involve altered endometrial effects and cervical mucus changes. However, taking Clomid increases a woman’s chances of having twins. According to statistics, Clomid can increase the chance of twins by 10%.

 

Early Treatment of PCOS Can Help Preserve Fertility

Fertilization process - PCOS conditionPolycystic Ovarian Syndrome is a prevalent condition in girls of adolescent age and women of reproductive age that is a prime causative factor of female subfertility. Millions of women around the world suffer from the devastating health and fertility effects of PCOS, but things are about to change in the near future.

A new study found out that the early diagnosis and treatment of polycystic ovary syndrome or PCOS may help prevent a later decrease in a woman’s fertility.

PCOS and Infertility

Women and girls with PCOS often have an abnormal amount of liver fat and abdominal visceral fat. Bringing down the amount of fat to normal levels restores ovulation and counters the symptoms of androgen excess, thereby possibly preventing future subfertility, as found in a new research from Spain. The findings of this study have been presented in Orlando Florida USA during ENDO 2017, the annual meeting of the Endocrine Society.

Professor of pediatrics Lourdes Ibáñez, M.D., Ph.D at the Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, in Barcelona, Spain, the study’s lead author said that PCOS is the main cause of female subfertility in women and girls diagnosed with it. She stated that if women and girls with PCOS are prescribed a low-dose combination of insulin-sensitizers and an anti-androgen such as SPIOMET, their ovulation would be restored following a reduction in ectopic fat. This return of ovulation can prevent future fertility issues and have to resort to expensive and time-consuming fertility treatments just to conceive.

Spanish Study Sheds New Light on Infertility Related to PCOS

Ibáñez and her colleagues picked out 36 young women with PCOS averaging 16 years of age, not sexually active, and not obese and enrolled them in their treatment plan. The study subjects had had their menstrual cycle for at least 2 years, and irregular menses and their excess body hair could not be linked to specific causes. 34 of the 36 girls completed the study.

The study respondents were randomized to receive one of two different drug combinations used for the study daily. One group was given a combined oral contraceptive pill containing 20 mcg ethinylestradiol plus 100 mg levonorgestrel and another group of study respondents was given SPIOMET, a combination of spironolactone 50 mg, pioglitazone 7.5 mg, and metformin 850 mg. The respondents were then encouraged to eat a Mediterranean diet and engage in regular exercise. They took the medications for a full year followed by another full year without medical intervention.

Researchers pored over the respondents’ weekly measurements of salivary progesterone and menstrual diaries. They counted the ovulations that occurred between 2 and 6 months after treatment and did it again at between 9 and 12 months after treatment. The researchers also assessed and noted circulating androgens, body composition, cholesterol and insulin, amount of abdominal fat, carotid artery thickness, and visceral and hepatic fat.

Results Can’t Be Ignored

The authors found out that prior to treatment, the respondents had more visceral and hepatic fat than age-matched controls, had altered markers of cardiovascular health, and had higher levels of androgens and insulin.

During treatment, those who took SPIOMET had a more normalized cardiovascular health, insulin and androgen levels, and lower levels of visceral and abdominal fat as compared to those who took the oral contraceptive combination.

The scientists also found out that those who have been taking SPIOMET had a 2.5X higher ovulation rate and 6X prevalence of normal ovulation as compared to those who were on the OCP medication. They had a higher prevalence of their menstrual cycles getting back to normal and staying within normal parameters for researchers to deduce that they have better fertility.

Polycystic Ovarian Syndrome Basics for a Fertility Doctor

                  Polycystic ovarian syndrome (PCOS) is a common disorder for females in the reproductive age. It can cause irregular menstruation and make it difficult for women to get pregnant. The cause of this disorder is unknown but it can be described as a genetic disorder. It can be commonly detected pelvic painusing ultrasound or other forms of pelvic imaging. There is approximately 20-33% of the population that is affected.

                  However, not all women with PCOS have the same clinical and biochemical features such as menstrual cycle disturbances, obesity, hirsutism, acne and abnormalities of biochemical profiles. The presentation of patients can be so different that one or any of the combinations may be present in association with an ultrasound picture of polycystic ovaries.

                  PCOS is familial and can exist without clinical signs. Most women have small cysts in their ovaries which are not released. With the multiple cysts over time, this disorder is hence called polycystic ovarian disease. The cysts are not harmful but many lead to hormone imbalances.

                  In PCOS, more androgens (male hormones) are made causing problem with ovulation, acne, and the growth of extra facial and body hair. Symptoms may be mild at first but most patients present with acne, weight gain, difficulty losing weight, extra hair on the face and body, thinning head hair, irregular periods, fertility problems and depression.

                  PCOS is diagnosed by asking the patient her history of past health, symptoms and menstrual cycles. A physical exam is conducted to look for signs of PCOS such as extra body hair and canstockphoto43917829possibly high blood pressure. A series of lab tests is also done to check blood sugar, insulin and other hormone levels. This can help to rule out other hormonal problems such as thyroid problems. A pelvic ultrasound is also used to look for cysts in the ovaries.

                  PCOS can be managed using a healthy lifestyle management such as encouraging regular exercise, having a healthy diet and controlling weight. These three steps are the key management for PCOS patients. Bad habits such as smoking should also be avoided. Doctors may prescribe birth control pills to reduce symptoms and metformin to help regulate menstrual cycles. If the patient is looking to conceive, fertility medication can also be prescribed. PCOS patients often report of feeling depressed and they are encouraged to participate in a support group.

                  PCOS is one of the commonest endocrine (hormonal) problems and women with PCOS are characterized by insulin resistance, central obesity, and dyslipidemia which appears to increase their risk of diabetes and heart disease. Patients should realize the importance of diet, activity, reduction of stress, behavior modification, social support from family and friends and ultimately, smoking cessation.

Pacific Reproductive Center offers top treatment for PCOS and helps people reach their fertility goals time and time again. Dr. Rifaat Salem is an exceptional fertility doctor with over twenty years experience. Call us today for top treatment!

 

References: