02 Apr Progesterone Therapy May Help Prevent Recurrent Pregnancy Loss
A study conducted by researchers at the Yale School of Medicine and the University of Illinois in Chicago found that the hormone progesterone improves the success for live births in women who suffer from recurrent pregnancy losses around the first four to six weeks of gestation.
The results from the clinical study were published in Fertility & Sterility in January 2017, which is the international journal of the American Society for Reproductive Medicine.
The participants in the study included 116 women who had experienced two or more pregnancy losses and they received a plant-derived form of progesterone. Women in the study who were attributed to having an abnormal uterine lining were administered the progesterone medication two days after they started ovulating. The reason for giving the medication at this time is because the lining of the uterus, called the endometrium, thickens and gets ready for a possible pregnancy.
Findings of the Study
The researchers believed that the progesterone caused the patient’s endometrial lining to produce more secretions which feed the Fetus up until the eighth week of pregnancy. Thereafter, from around nine to 10 weeks gestation, the mother’s blood supply feeds the developing fetus.
After administering the progesterone to these women the following findings were made:
- The uterine lining which was previously assessed to be inappropriate for implantation of a fertilized embryo now seemed more conducive to the task.
- The uterus produced more endometrial secretions and, therefore, made more nutrients available for the fetus to feed on in order to develop further.
The researchers were very pleased to demonstrate that their findings reinforced the evidence for progesterone to show that this inexpensive drug could be beneficial and safe for women with a history of recurrent pregnancy loss.
The next step to prove that progesterone would indeed result in reduced pregnancy losses would be to perform a prospective randomized trial study to validate the findings of the one mentioned here.
Causes of Recurrent Pregnancy Loss
Recurrent pregnancy loss can be caused by the following issues:
- Genetic – abnormal karyotype of the embryo. At least 50 percent of all first trimester spontaneous miscarriages are due to this issue.
- Immunological – autoimmune conditions such as antiphospholipid syndrome.
- An anatomical defect of the uterus.
- Exposure to environmental factors such as chemical and toxins.
- Endocrine – poorly controlled diabetes and thyroid diseases.
- Hematologic – abnormalities involving the placental blood supply.
- Infections – although this is a rare cause of recurrent pregnancy loss, it is still a cause nonetheless.
Pacific Reproductive Center
Pacific Reproductive Center is a world-class medical facility where specialist physicians consult with and manage couples and individuals who struggle to conceive. The center specializes in infertility cases and doctors manage both males and females depending on the cause of infertility.
Recurrent pregnancy loss is one such situation managed by the specialists at the center and causes of the problem are investigated and managed accordingly in order to improve the chances of conception. Patients are interviewed, examined, investigated, and managed with care and compassion in order to achieve optimal results.